Just this morning upgraded to 5.2.4.5 and it didn't fix it. Launching blueiris from desktop still works fine, just after reboot I have to go in the windows service panel to manually start the service and it started fine.
Out of curiosity I went to windows event viewer and found this,
Faulting application path: C:\Program Files\Blue Iris 5\BlueIris.exe
Faulting module path: C:\WINDOWS\System32\ucrtbase.dll
I've had blueiris set up like this for a year now, run as windows service and RDP to it if need to change anything then launch the desktop version. This problem seemed only occurred recently probably in last few days as I rarely reboot the blue iris computer.